The Ultimate Vampire Resource and Directory

After their mother's death in a suspicious fire that burns down their house, Dean and Sam Winchester live a life on the road with their father as they grow up. Years pass and the boys team up to find their father, John, who goes missing on a hunting trip. However, their father is not a typical hunter: he hunts supernatural creatures like ghosts, vampires, and spirits and he's trained his sons to do the same. Along the way, Sam and Dean save innocent people, fight creatures and ghosts, and collect clues to their father's whereabouts. Sam begins to mysteriously develop psychic abilities and visions as they travel. They eventually find and reunite with their father, who reveals that the creature that killed Sam and Dean's mother years earlier is a yellow-eyes demon (Azazel) and the only thing that can kill him is a legendary gun called the Colt.

There has been a total of 7 seasons so far and a anime. After the 1st season the story grows for example in season 5, Sam and Dean try to stop the apocalypse and prevent the rise of Lucifer.