Baron von Frankenstein (voice of Boris Karloff) decides to retire, leaving the monster business to his nerdy nephew, Felix Flankin (Allen Swift). Frankenstein plans to announce his decision at a convention of monsters that includes his creature and the creature's more intelligent mate (Phyllis Diller), Frankenstein's seductive laboratory assistant Francesca (Gale Garnett) (resembling a caricature of Ginger Grant from Gilligan's Island, and playing the part of femme fatale), Dracula, the Werewolf, the Creature from the Black Lagoon, The Invisible Man, The Hunchback of Notre Dame, Dr Jekyll & Mr Hyde, The Mummy, It (a knock-off of King Kong), and many more. However when Felix proves to be an incompetent (and unsuitably kind-hearted) human, the monsters plot to eliminate him and gain control of Frankenstein's latest discovery: the secret of total destruction!
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