Biological factor for Autism found... 23:24 Dec 13 2010
Times Read: 591
As some of you know my son has Autism, so this is something that is near and dear to my heart...
This is a news article in The Huffington Post by
Mark Hyman, MDPracticing physician
Posted: December 11, 2010 11:37 AM
Imagine being the parent of a young child who is not acting normally and being told by your doctor that your child has autism, that there is no known cause, and there is no known treatment except, perhaps, some behavioral therapy. That is exactly what Jackson's parents were told as their 22-month-old son regressed into the non-verbal psychic prison of social withdrawal, disconnection, and repetitive behaviors typical of autism.
While we don't have all the answers, and more research is needed to identify and validate the causes and treatment of autism, there are new signs of hope. A study just published in The Journal of the American Medical Association by researchers from the University of California, Davis called "Mitochondrial Dysfunction in Autism" (i) discovered a profound and serious biological underpinning of autism -- an acquired loss of the ability to produce energy in the cells, damage to mitochondria (the energy factories in your cells), and an increase in oxidative stress (the same chemical reaction that causes cars to rust, apples to turn brown, fat to become rancid, and skin to wrinkle). These disturbances in energy metabolism were not due to genetic mutations, which is often seen in mitochondrial problems, but a condition the children studied acquired in utero or after birth.
Bottom line, if brain cells cannot produce enough energy, and there is too much oxidative stress, then neurons don't fire, connections aren't made and the lights don't go on for these children. In fact, this problem of energy loss is found in most chronic disease and aging -- from diabetes to heart disease to dementia. Brain function and neurodevelopment in particular are highly dependent on energy.
This is exactly the problem, I documented and found in Jackson when I first saw him. He had a profound loss of energy in his cells (particularly his brain cells), and indicators of severe oxidative stress. This is the same problem many other researchers have found in similar studies. (ii) Despite the evidence, most physicians don't test for mitochondrial dysfunction, oxidative stress or other myriad factors commonly found in autistic children.
Let's look more closely at what this new study in The Journal of the American Medical Association tells us about mitochondrial dysfunction, and how this may lead us to new methods of treatment -- methods similar to the ones I used to help reverse Jackson's autism.
Autism: Brain Disorder or Body-Based Biological Illness?
The big debate (iii) that ranges in autism circles is about whether or not autism is a fixed, irreversible brain-based genetic disorder, or a systemic, reversible body-based biological condition that has identifiable causes, measurable abnormalities, and treatable dysfunctions. In other words is autism a life sentence or a reversible condition?
Many studies have illuminated the causes and possible treatments for autism, but mainstream physicians or scientists ignore most of this data. This new study, breaks new ground because it was published in one of the world's major medical journals.
In it researchers from UC Davis examined children two to five years of age from the Childhood Autism Risk From Genes and Environment (CHARGE) study in California -- a population-based, case-control investigation with confirmed autism cases and age-matched, genetically unrelated, typically developing controls, that was launched in 2003 and is still ongoing. What they discovered was the aforementioned mitochondrial dysfunction that lead to problems with energy. Interestingly, these abnormalities were not found in neurons on a brain biopsy but from examining white blood cells called lymphocytes. This means the energy deficit was a systemic problem -- not one residing solely in the brain.
This study forces the question: How do children acquire energy deficits that affect their whole system, not just the brain?
The causes of mitochondrial dysfunction are well known, specifically as it relates to metabolism and the brain, and I have documented them in my books "UtraMetabolism" and "The UltraMind Solution." They include environmental toxins (iv) -- mercury, lead and persistent organic pollutants(v) -- latent infections, gluten and allergens (which trigger inflammation) sugar and processed foods,(vi) a nutrient-depleted diet(vii) and nutritional deficiencies.(viii) These are all potentially treatable and reversible causes of mitochondrial dysfunction that have been clearly documented.
I found all these problems in Jackson, and over a period of two years we slowly unraveled and treated the underlying causes of his energy loss which included gut inflammation, mercury, and nutrient deficiencies. Over time, the tests for his mitochondrial function and oxidative stress (as well as levels of inflammation and nutrient status) all normalized. When they became normal, so did Jackson. He went from full-blown regressive autism to a normal, bright beautiful six-year-old boy.
What it Means if Autism Can be Reversed
This is just one story, but if autism can be reversed in one child, if there is any possibility of effective treatments or a potential cure, it forces us to ask critical questions: How did this happen? Can it happen in other children? What were the biological patterns found and how were they treated?
The emotional and financial costs of autism for families and societies is staggering. Now one in five -- or 20 percent -- of children have some neurodevelopmental disorder. How can we sidestep our scientific and moral obligation and sit back and accept the limited resources allocated by the National Institutes of Health ($5.1 billion for cancer, but only $141 million for autism) and society as a whole.
Most neurodevelopmental disorders have common roots. But looking at only one aspect of such conditions will not solve the problem of autism. Current autism research is based on an outdated approach -- one that is something like blind men examining the proverbial elephant. Each researcher works in his or her own silo examining different factors and coming to different conclusions. Research that integrates, synthesizes and examines all the data on causes and potential treatments is practically non-existent.
The mitochondrial dysfunction identified in the JAMA study I've been talking about is ultimately only one downstream symptom of many upstream causes. Other researchers have found systemic inflammation,(ix) brain inflammation,(x) gut inflammation,(xi) elevated levels of toxins and metals, gluten and casein antibodies,(xii) nutrient deficiencies including omega-3 fats,(xiii) vitamin D,(xiv) zinc, and magnesium, and collections of metabolic dysfunction related to quirky genes that make it difficult to perform chemical reactions essential for health in the body such as methylation and sulfation.(xv)
The take home message here is that the answer to autism and other neurodevelopmental disorders will not be found in one of these factors, but in all of them taken together in varying degrees in each individual. There is no such thing as "autism." Rather there are "autisms" -- different patterns of biological dysfunction unique to each child that result in multiple insults to the brain that all manifest with symptoms we call autism.
Future research must synthesize current data and design relevant whole systems research studies that don't focus on a single factor, but examine all the factors together. Then we must apply these findings in a comprehensive fashion, as is being done by many practitioners today who work in parallel -- rather than in collaboration with -- conventional approaches and often achieve remarkable results.
To close, I'd like to share Jackson's story, as told by his father. I have documented this case report in a peer reviewed published paper which you can read if you are interested in the details of the case.(xvi) It is called "Autism: Is it All in the Head?" and it can be found at http://drhyman.com.
But more important than my paper is Jackson's story and his beautiful smile.
To your good health,
Mark Hyman, MD
References
(i) Giulivi, C., Zhang, Y.F., Omanska-Klusek, A., et al. 2010. Mitochondrial dysfunction in autism. JAMA. 304(21):2389-96.
(ii) Haas, R.H. 2010. Autism and mitochondrial disease. Dev Disabil Res Rev. 16(2):144-53.
(iii) Herbert, M. 2005. Autism: A brain disorder or a disorder that affects the brain. Clinical Neuropsychiatry 2(6): 354-379
(iv) Landrigan, P.J. 2010. What causes autism? Exploring the environmental contribution. Curr Opin Pediatr. 22(2): 219-25. Review.
(v) Kern, J.K., Geier, D.A., Adams, J.B., et al. 2010. Toxicity biomarkers in autism spectrum disorder: A blinded study of urinary porphyrins. Pediatr Int. Jul 4 Epub ahead of print.
(vi) Feillet-Coudray, C., Sutra, T., Fouret, G., et al. 2009. Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems. Free Radic Biol Med. 46(5): 624-32.
(vii) Dufault, R., Schnoll, R., Lukiw, W.J., et al. 2009. Mercury exposure, nutritional deficiencies, and metabolic disruptions may affect learning in children. Behav Brain Funct. 27(5): 44.
(viii) Ames, B.N. 2004. A role for supplements in optimizing health: the metabolic tune-up. Arch Biochem Biophys. 423(1): 227-34. Review.
(ix) Careaga, M., Van de Water, J., and P. Ashwood. 2010. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics. 7(3): 283-92. Review.
(x) Li X., Chauhan, A., Sheikh, A.M., Patil, S., et al. 2009. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 207(1-2): 111-6. Jan 20 Epub ahead of print.
(xi) Ashwood, P., Anthony, A., Torrente, F., and A.J. Wakefield. 2004. Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol. 24(6): 664-73.
(xii) Jyonouchi, H., Sun, S., and N. Itokazu. 2002. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology. 46(2): 76-84.
(xiii) Bell, J.G., MacKinlay, E.E., Dick, J.R., et al. 2004. Essential fatty acids and phospholipase A2 in autistic spectrum disorders. Prostaglandins Leukot Essent Fatty Acids. 71(4): 201-4.
(xiv) Cannell, J.J. 2008. Autism and vitamin D. Med Hypotheses. 70(4): 750-9.
(xv) James, S.J., Melnyk, S., Jernigan, S., et al. 2006. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 141B(8): 947-56.
(xvi) Hyman, M.A. 2008. Autism: is it all in the head? Altern Ther Health Med. 14(6): 12-5.
COMMENTS
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ladySnowStrixx
02:35 Dec 14 2010
WOW, that was great , I have worked with Autism children and This is great news .it will be even better when they find a cure.
TheTemptress
02:39 Dec 14 2010
Yes it would be, however I know this is going to sound funny, but I'm not sure I want Joshua cured... I love who he is and if he's cured he may not be the same as he is now...
SLEEPEREFFECT
04:22 Dec 14 2010
very very interesting
Bellanova333
19:23 Dec 14 2010
thank you for sharing this... I am actually in the process of getting my two sons tested for high functioning autism... I do know what you mean though, I wouldn't want mine to change either ; ) they are such a riot (:
PAGAN
19:32 Dec 14 2010
WOW. This is great news at long last. However, it will be many years before treatments will be approved by the AMC or BMA (UK). That said, it may be the answer to something that has puzzled researchers and physicians, psychologists since 1940s when Kanner first recognised the condition now known as Autistic Spectrum Disorder.
I too worked with children who had profound autism. I loved how they were with their autism and I understand totally how you say that Joshua would maybe not be the Joshua you know and love without autism. It takes a courageous mom to admit that and I hope folk understand that autism does not make a persons character any less loveable. x
MasterMel2
22:28 Jan 06 2011
I have volunteered with autistic children, and my good energy, and thoughts are with you.